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Environmental ScienceBiologyMedicine

Nutrient-driven small-colony variants as an adaptive outcome in Carbapenem-resistant Acinetobacter baumannii

Samyar Moheb, Shayra D. Sanchez, Irene Luu, Azadeh Varnado, G. Traglia, K. Lopez, J. Escalante, Cecilia Rodriguez, Marisel R. Tuttobene, M. Tolmasky, R. Bonomo, L. Actis, Gauri G. Rao, F. Pasterán, M. S. Ramírez

2026.5.1Current Research in Microbial Sciences

DOI: 10.1016/j.crmicr.2026.100614

Abstract

Highlights • Vitamin B12 induces stable small-colony variants (SCVs) in CRAB.• SCVs exhibit reduced cefiderocol killing and regrowth.• Mutations affect iron uptake, envelope structure, and metabolism.• Co-exposure enriches SCVs with siderophore and BfmRS changes.• Nutrients modulate antibiotic efficacy and persistence in CRAB.

Citation format

MOHEB, Samyar, et al. Nutrient-driven small-colony variants as an adaptive outcome in carbapenem-resistant acinetobacter baumannii. Current Research in Microbial Sciences, 2026, 10: 100614.