Racism-Related Concern for Children and Central Hemodynamics in African American Women: A Longitudinal Study.

OBJECTIVE African American women experience disproportionate cardiovascular disease risk, and altered central hemodynamics signal early vascular aging. For African American mothers, concern about their children's exposure to racism represents a salient psychosocial stressor, but its vascular consequences are unclear. We examined whether greater racism‑related Concern for Children (CFC) was associated with adverse longitudinal changes in central hemodynamics.

METHODS African American mothers aged 30-46 years (n=236) underwent assessments of central systolic blood pressure (cSBP), augmentation index (AIx), pulse pressure amplification (PPA), and pulse wave velocity (PWV; n=205) at baseline and 4±1 years later. CFC was measured continuously (range 0-24) and categorically (high vs. low). Multivariable linear regression models examined associations between CFC and changes in central hemodynamics, adjusting for baseline values and sociodemographic, clinical, and psychosocial covariates. Logistic regression evaluated CFC and odds of newly developed high‑risk PPA (PPA<1.3).

RESULTS In fully adjusted models, greater CFC was associated with larger increases in AIx (b=0.30, 95% CI [0.11, 0.48]; P=0.002). At follow‑up, women with high CFC had AIx values 3.9 percentage points higher than those with low CFC (P=0.005). CFC was also associated with declining PPA (b=‑0.003, 95% CI [‑0.005, ‑0.001]; P=0.024) and greater odds of newly developed high‑risk PPA (OR=1.08, 95% CI [1.01, 1.15]; P=0.033). No associations were observed for cSBP or PWV.

CONCLUSIONS Greater racism‑related concern for children is associated with signs of early vascular aging in African American mothers, highlighting the cardiovascular consequences of racism‑related maternal stress.