Drosha Dice(r)ing lipid metabolism in the liver.

SREBP transcription factors are key regulators of lipid metabolism and play a central role in metabolic dysfunction-associated steatotic liver disease (MASLD). In a recent issue of Molecular Cell, Nie et al.1 have discovered that Drosha, known for microRNA processing, regulates the maturation and activation of SREBP1 in the liver, and this seems to be important in MASLD.