624P Longitudinal medical cannabis use patterns and patient characteristics among Florida Medicare beneficiaries with incident breast cancer

Methods: Consecutive newly diagnosed breast cancer patients completed surveys at baseline (after first presentation), midpoint (after MDT review and treatment planning), and endpoint (during systemic treatment).Outcomes were understanding/ preparedness (5-point scale), baseline anxiety (5-point scale) with follow-up emotional change (improved/neutral/worsened), comfort communicating with the care team (yes/no), and satisfaction/helpfulness of navigator support (5-point scale).Within-patient changes were analyzed using Friedman tests for ordinal outcomes and Cochran's Q/McNemar tests for binary outcomes.Results: Surveys were completed by 118 (baseline), 100 (midpoint), and 98 (endpoint) patients (follow-up 84.7% and 83.1%).Understanding/preparedness improved from 1.751.08 at baseline to 3.691.17at midpoint and 3.621.03at endpoint (Friedman 2 (2)=92.51;p<0.001).Satisfaction increased from 4.400.78 to 4.660.59( 2 (2)=10.22;p=0.006); midpoint helpfulness was 4.620.74.At baseline, 65.3% were very/extremely anxious.Emotional well-being improved for 49.0% at midpoint and 59.2% at endpoint; 12.0% and 15.3% reported worsening.Comfort communicating increased from 84.7% to 93.0% and 92.9% (Cochran's Q=2.17; p=0.337).At the endpoint, 100% reported a positive impact of navigation; suggested improvements centered on streamlining investigations and reducing delays.Conclusions: Patient navigation embedded within MDT care was associated with large early gains in patient-reported understanding and very high satisfaction in an LMIC comprehensive cancer center.Scale-up should be paired with pathway optimization and proactive psychosocial support for patients with persistent distress.