Impact of comprehensive phytonutrient support on the psycho-emotional and somatic condition of women with polycystic ovary syndrome during long-term use of oral contraceptives

Polycystic ovary syndrome (PCOS) requires lifelong management. Prolonged use of combined oral contraceptives (COCs, the first-line therapy) frequently induces side effects that diminish patient adherence to treatment.The objective: to investigate the effect of the “Elefteria Accept” dietary supplement on the quality of life and the management of common COC-associated symptoms in women with PCOS.Materials and methods. This 90-day observation included 63 patients (aged 18–35 years) with PCOS who took COC therapy. The main group (n = 32) received “Elefteria Accept” (1 capsule daily) adjunctive to COCs, while the control group (n = 31) continued with COCs alone. Patient status was evaluated using the HRQOL-4 questionnaire and a 5-point scale assessing the severity of 11 distinct symptoms.Results. Groups were statistically comparable at baseline (p > 0.10). In the main group, Healthy Days increased from 15.52 ± 3.61 to 22.52 ± 2.36 by day 90 (p < 0.001), while remaining stable in the control group (14.50 ± 5.15 vs 14.47 ± 4.73; p = 0.984). In the main group, a significant reduction in 8 out of 11 symptoms, notably mood swings (Δ = –0.87; p < 0.001), mastodynia (Δ = –1.03; p < 0.001), and leg heaviness (Δ = –1.03; p < 0.001) was found. In the control group, leg heaviness significantly increased (Δ = +0.25 ± 0.51; p = 0.011).