Synthesis and Anticancer Effect of a Vindoline-Based Bis-Alkylated Resorcinol Derivative

Alkylation of the simple polyphenol model resorcinol with 10-chloroacetamidovindoline resulted in the corresponding O,O-disubstituted derivative containing two elements of the Vinca alkaloid. The in vitro anticancer activity of the hybrid was investigated on the NCI-60 human tumor cell line panel, and the most important value was obtained on UO-31 renal cancer cells (50% growth inhibition GI50 = 0.893 µM).