Liquid Biopsy Biomarkers as Predictors of TNBC Recurrence: A Systematic Review.

INTRODUCTION Triple-negative breast cancer (TNBC) is associated with high recurrence and mortality. Liquid biopsy biomarkers, such as circulating tumor DNA (ctDNA), cell-free DNA (cfDNA), and microRNAs (miRNAs), offer noninvasive tools for monitoring TNBC.

METHODS A systematic review on liquid biopsy in TNBC was conducted and analyzed using PRISMA guidelines and later assessed via the EPHPP tool.

RESULTS Across 20 studies, ctDNA was a strong predictor for poorer disease-free survival (DFS) and relapse-free survival (RFS). Other biomarkers, including cfDNA and miRNAs, also showed prognostic value.

CONCLUSION Liquid biopsy, particularly ctDNA, is a valuable predictor of TNBC recurrence, supporting noninvasive monitoring and prognosis.