Jiaojiao Sha, Zijin Geng, Shanyu Qi, Liangjia Du, Qianqian Hu, Minqi Cai, Dezhu Chen, Yiqiang Chen, Siyuan Liu, Hongyan Song, Tianze Ling, Cheng Chang, Bing Bai
2026.6.8ACS Omega
Abstract
-glycans found at the N304 site of lecanemab of the heavy chain. Further analysis by MSFragger identified other modifications and additional glycosites. These results provide data as resource for the identification of critical quality attributes of lecanemab in studying its therapeutic effectiveness, side effects, and possible batch-to-batch qualities.
Citation format
SHA, Jiaojiao, et al. Characterization of the anti-alzheimer drug lecanemab by mass spectrometry. ACS Omega, 2026.