Purinergic signaling modulates endothelial-to-mesenchymal transition in human aortic valve endothelial cells

Highlights • Dysregulation of the purinergic signaling system leads to EndMT in VECs.• First study linking purinergic signaling to EndMT in human VECs.• Enhanced ATP impact promotes mesenchymal phenotype in VECs.• Modulation of ectonucleotidase function alters EndMT-associated transcription factor expression in VECs.