Medicine

Breaking the barrier: Synergistic 2B4.4-1BB signaling potentiates HER2-CAR NK cells to penetrate and destroy ADCC-resistant tumors.

Bence Gergely, Márk A Vereb, István Rebenku, Á. Szöőr, G. Vereb

2026.7.1CANCER LETTERS

DOI: 10.1016/j.canlet.2026.218534

Abstract

• Dual 2B4·4-1BB signaling reprograms HER2-CAR NK-92 cells for durable antitumor power • Synergistic costimulation drives deep infiltration of mAbs resistant tumor spheroids • Dual 2B4·4-1BB CAR NK-92 therapy achieves long-lasting tumor remission • This next-generation CAR-NK design overcomes immune and TME derived resistance

Citation format

GERGELY, Bence, et al. Breaking the barrier: Synergistic 2B4.4-1BB signaling potentiates HER2-CAR NK cells to penetrate and destroy ADCC-resistant tumors. CANCER LETTERS, 2026, 651: 218534.