Results of Radiofrequency Ablation Treatment for Patients with Inoperable Non-Small Cell Lung Cancer at Nghe an Provincial Oncology Hospital, Vietnam

Background: To evaluate the results of Radiofrequency Ablation (RFA) treatment for patients with inoperable Non-Small Cell Lung Cancer (NSCLC) at Nghe An Provincial Oncology Hospital. Methods: An uncontrolled clinical intervention study, comparing before-and-after results on 63 inoperable NSCLC patients who were treated with radiofrequency ablation at Nghe An Provincial Oncology Hospital from January 2014 to August 2022. Results: In the 63 patients studied, the average age was 64.8±7.9 yrs. Men accounted for 82.5%. The average tumor size was 4.45±1.86 cm. The group of tumors with a size of 5 cm accounted for 39.7%, from 3 cm to less than 5 cm, and tumors <3 cm all had a rate of 30.2%. There were 34 cases of partial response (54.0%), 31.7% of intact disease, and 14.3% of progressive disease. There was no complete response. The results of multivariate Cox regression analysis showed that tumor size <3 cm (HR=0.258; 95%CI:0.094-0.703), mild disease stage (Stage I/II/III) (HR=0.263; 95%CI: 0.099-0.696) and having a treatment response after RFA (HR=0.332; 95%CI: 0.160-0.690) were factors that affect the patient’s overall survival time. Conclusion: RFA is a minimally invasive treatment method that is effective in local tumor control and survival time.