Assessing the Histopathological Patterns of Lesions in Hystrectomy Specimen in Tertiary Care Hospital

Objective: This research designed to investigate the frequency and histopathological spectrumof hysterectomy specimens at DDRRL, DUHS, Karachi. Methodology: A descriptive cross-sectional study was performed over 10 months from Janu2023 to October 2023 at DDRRL, DUHS. A total of 259 hysterectomy specimens were included.Patient demographic and clinical data were collected, and specimens were processed forhistopathological examination. Data analysis was achieved by using SPSS version 26, employingdescriptive statistics. Results: Mean age of patients was 40.02 years. The most common age group undergoinghysterectomy was 31-40 years (35.5%). Total Abdominal Hysterectomy with Bilateral SalpingoOophorectomy (TAH+BSO) was the predominant procedure (75.3%). Most patients had highparity (56.8% with five or more children). The primary clinical indications were abnormaluterine bleeding (AUB) (42.9%) and fibroids (29.7%). Histopathologically, endometrial lesionswere the most frequent (44.4%), followed by cervical (20.5%), myometrial (18.1%), and ovarianlesions (17.0%). Conclusion: Hysterectomy is primarily indicated for AUB and fibroids in the studiedpopulation. Histopathological examination predominantly reveals endometrial pathology. Thefindings emphasize the importance of histopathological evaluation in hysterectomy specimens toensure accurate diagnosis and appropriate postoperative management.