Computer-based systematic analysis of fundamental and clinical studies on the pharmacology of alloferon

Background . Alloferon is a naturally occurring peptide that exhibits pronounced antiviral and anti-inflammatory properties. By inducing interferon biosynthesis, alloferon activates lymphocyte immunity. Objective : To systematize all available scientific data on the pharmacology of alloferon. Material and methods . A set of all currently available publications on alloferon from both fundamental and clinical studies (122 publications in PubMed/MEDLINE and eLibrary) was examined. After downloading this sample, it was systematically analyzed using the topological and metric approaches to heterogeneous feature descriptions developed by Yu.I. Zhuravlev and K.V. Rudakov. Results . A metric analysis of the terms most informative for describing the pharmacology of alloferon revealed its complex antiviral action, involving the suppression of the replication of human papillomavirus virus (HPV), herpes simplex virus (HSV), and hepatitis B and C viruses. HPV and HSV infections stimulate the development of dysplasia and other cervical tissue lesions, endometritis, and recurrent miscarriage. Thus, the use of alloferon in treating these gynecological pathologies has proven highly effective. Additionally, alloferon successfully treats mixed viral and bacterial-viral infections in prostatitis, eye diseases (e.g., viral iridocyclitis, anterior/ posterior uveitis), erysipelas, which is a streptococcal infection of the soft tissues, and others. Possible molecular mechanisms of alloferon's action include regulating the gene expression of antiviral and humoral immunity, as well as the body's inflammatory response. Notably, alloferon stimulates the immune system while preventing excessive inflammation, which can lead to tissue degradation, multiorgan pathology, and aggravated viral infections. Furthermore, research results from fundamental and clinical studies suggest using alloferon in complex antitumor therapy. Conclusion . Alloferon is an immune and inflammatory modulator that has demonstrated high efficacy against viral and mixed infections with a good safety profile.