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Ferroptosis-Associated Fibroblast Activation and Transcriptional Remodelling in Human Heart Failure: A Proof-of-Concept Study.

K. Karampinos, G. Georgiopoulos, M. Kallikourdis, Rijan Gurung, Roger Foo, D. Cokkinos, Dimitrios Farmakis

2026.5.1EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

DOI: 10.1111/eci.70213

Abstract

Single-cell analysis of human heart failure identifies a fibroblast-enriched ferroptosis signature that distinguishes DCM from controls and reveals a pseudotime trajectory linking ferroptotic stress to progressive fibroblast activation and pro-fibrotic remodelling.

Citation format

KARAMPINOS, K., et al. Ferroptosis-associated fibroblast activation and transcriptional remodelling in human heart failure: A proof-of-concept study. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2026, 56 5(5): e70213.