MedicineBiology
Tao Xu, Qinxin Sun, Shuhao Zhang, Tingzhuo Liu, Xiaoou Sun, Xusheng Wang, Bin Lin, Zhongjie Liu, Juan Wang, Guodong He, Xiangyu Liu
2026.5.13Cell Discovery
Abstract
, G protein-coupled receptors (GPCRs) play pivotal roles in regulating physiological processes, and comprehensive statistical analyses indicate that ~36% of approved drugs exert their therapeutic effects by acting on GPCRs, collectively contributing to over 27% of the global pharmaceutical market revenue 1,2 . Over
Citation format
XU, Tao, et al. A negative survival pressure selection system enables GPCR antagonist screening. Cell Discovery, 2026, 12(1).