Patent Landscape of Co-Amorphous Drug Formulations (1993-2025): Comparative Analysis Across the US, China, Japan, Australia and Insights for R&D & IP Management

A co-amorphous substance is a new drug-delivery technology for pharmaceutical formulations that consists of a homogeneous, single-phase mixture of two or more lowmolecular- weight molecules. Such systems have the potential to improve the dissolution rate, solubility, and bioavailability of poorly water-soluble drugs. Additionally, they provide greater physical stability than the crystalline and amorphous forms of the same drug. This study employed systematic patent landscape analysis regarding the development of co-amorphous material systems. It contains information from 10 projects, compiled in Microsoft Excel, and records patent submissions compiled from 1993 through early 2025, covering the four major countries USA, China, Japan, and Australia. These Patents landscape provides information on granted patents and applications by applicant name and number, filing and publication dates, and publication type (A1/B2). The patent landscape analysis shows that patent applications increased in both the US and China post-2020. In Japan, there was a more equal distribution of patents between industry and academia than in Australia, where many patents were filed by industry. The primary applicants for these patents include Zerion Pharma APS and MSN Laboratories. These patents provide information on the application of "Co-Amorphous Technology" within both the nutraceutical and agrochemical industries. The increase in the patent growth trends indicated increasing recognition of coamorphous systems to enhance drug performance. The geographic distribution highlighted different models of innovation, from academia-industry collaborations to industry-dominated research. The participation of leading pharmaceutical companies further marked the commercial feasibility of such systems. This patent landscape analysis provides essential information on innovation trends in co-amorphous systems. This information can be used for planning in the pharmaceutical research and technology development fields.