Structural design and mechanical analysis of cerebral venous sinus thrombolytic stents

Cerebral venous sinus thrombosis (CVST) poses treatment challenges due to fundamental anatomical differences between venous and arterial systems, for which conventional arterial thrombectomy devices are suboptimal. We present a manually adjustable braided NiTi stent retriever designed for CVST that enables real-time control of radial force and thrombus engagement. Finite element analysis demonstrated uniform stress distribution under tensile, compressive, and bending loads. Mechanical tests confirmed low radial force and high flexibility, while deployment in a human venous sinus model showed excellent conformability. This stent overcomes key limitations in venous thrombectomy, providing a promising foundation for CVST-specific devices.