Ana García-Bautista, Aiora Cenigaonandia-Campillo, A. Río-Vilariño, Lara Sanz-Criado, Marta Selva-Giménez, Raquel Perez-Antolín, A. Cebrián, L. García-García, M. Fernández-Aceñero, Natalia Baños-Herraiz, Lorena Mozas-Vivar, E. Núñez-Delicado, J. García-Foncillas, Ó. Aguilera
2026.4.30NEOPLASIA
tlooto Summary
ACLY regulates MDR1 through acetyl-CoA–dependent chromatin control through acetyl-CoA–dependent chromatin control and vitamin C suppresses tumor growth and MDR1 in CRC PDX models.
Abstract
Highlights • ACLY links metabolism to MDR1 expression in KRAS-mutant CRC.• ACLY regulates MDR1 through acetyl-CoA–dependent chromatin control.• Vitamin C disrupts citrate–ACLY metabolism and reduces MDR1 levels.• ROS partially contribute to vitamin C–induced MDR1 downregulation.• Vitamin C suppresses tumor growth and MDR1 in CRC PDX models.
Citation format
GARCÍA-BAUTISTA, Ana, et al. Metabolic regulation of histone acetylation by ACLY supports MDR1 expression in colorectal cancer and highlights a targetable vulnerability. NEOPLASIA, 2026, 77: 101314.