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PCBP2 mediates MTUS1 degradation through 3'-UTR binding to restrict pyroptosis and augment malignant progression in esophageal squamous cell carcinoma.

Chenming Jiang, Quan Lu, An Wang, Hao Chen, Lishuai Yao

2026.3.19Esophagus

DOI: 10.1007/s10388-026-01188-1

tlooto Summary

PCBP2 suppresses MTUS1 expression via 3'UTR-mediated degradation, inhibiting pyroptosis and promoting ESCC progression, suggesting the PCBP2/MTUS1 axis as a potential therapeutic target to enhance chemotherapy efficacy.

Abstract

Abstract is not available.

Citation format

JIANG, Chenming, et al. PCBP2 mediates MTUS1 degradation through 3'-UTR binding to restrict pyroptosis and augment malignant progression in esophageal squamous cell carcinoma. Esophagus, 2026, 23(3): 653–668.