Simultaneous Detection of Dopamine and Uric Acid at a Glassy Carbon Electrode Modified With a Novel Polymerized Copper Phthalocyanine–Multiwall Carbon Nanotubes Complex

Uric acid (UA) is the final product of purine metabolism, while dopamine (DA) is a neurotransmitter synthesized through the tyrosinemetabolic pathway; nevertheless, both compounds commonly coexist in serum and in the extracellular fluid of the central nervous system and are important biomarkers for clinical diagnosis. Some diseases of the human body are due to abnormal levels of UA and DA. Thus, the clinical diagnosis of some diseases needs a sensitive and simultaneous monitoring of UA and DA. This research introduces a new conductive composite film comprising multiwalled carbon nanotubes (MWCNTs) functionalized with MWCNTs and copper monoamide phthalocyanine covalently linked to an acrylate polymer (MWCNTs‐CuMAPc‐PnBA). The film was deposited onto a glassy carbon electrode (GCE) and employed for the concurrent detection of UA and DA. The GCE with modifications exhibits acceptable electrocatalytic performance in the detection of DA and UA. Low detection limits were achieved at 0.174 µM of DA and 6.87 µM of UA, and the linear detection ranges of DA and UA are 5–200 µM and 20–250 µM, respectively. The proposed sensing system based on the modified GCE offers promising results for rapid, cost‐effective, and selective simultaneous detection of UA and DA. Also, the complex‐modified electrode showed satisfactory results in detecting simultaneously DA and UA in human urine real samples.