MyADHD: A therapist-guided internet-delivered intervention for adult ADHD — Results from a single-armed open clinical trial in routine care

Background Adults seeking treatment for the syndrome of ADHD often face barriers to accessing evidence-based care. Digital interventions may help address these challenges, but their effectiveness in routine clinical settings remains underexplored. Objective This study evaluated pre–post change in ADHD symptoms and quality of life following a therapist-guided internet-delivered intervention for adults with ADHD in routine care. A secondary aim was to examine demographic, contextual, and clinical predictors of treatment response. Methods In an open, single-arm trial, 228 adults with ADHD received a 7–10 week therapist-guided intervention. ADHD symptoms (Adult ADHD Self-Report Scale; ASRS) and quality of life (Adult ADHD Quality of Life questionnaire; AAQoL) were assessed at baseline, mid-treatment, and post-treatment. Random intercept, fixed slope linear mixed models were estimated to examine change over time and impact of potential predictors. Results Participants showed moderate improvements in ADHD symptoms (d = −0.47) and quality of life (d = 0.45). Inattention and productivity domains improved most. Reliable change was observed in 23.9% of completers for ADHD symptoms and 31.0% for quality of life. No demographic, contextual, or clinical variables significantly predicted treatment response. Conclusions In this open, single-arm study conducted in routine clinical care, therapist-guided internet-delivered treatment was associated with moderate improvements in ADHD symptoms and quality of life among adults with ADHD. Findings were comparable across baseline levels of comorbidity, treatment expectation and route to care. Given the absence of a control group, findings should be interpreted cautiously, and causal inferences cannot be drawn. Replication in adequately powered randomized controlled trials is needed to determine the intervention's efficacy and to clarify for whom and under what conditions it is most effective.