Multifaceted Exploration of a New Schiff Base and Its Complexes: Thermal Properties and Biomedical Potential

This study presents the thermal and biomedical evaluation of a newly synthesized imine ligand and its six metal complexes. The synthesis and spectral data are detailed in Part 1 of this work. Here, advanced analyses such as LC‐MS, SEM, and XRD were used for physicochemical characterization. Thermal stability was assessed using TGA, DTA, and DTG under inert conditions, with kinetic parameters calculated via the Kissinger−Akahira−Sunose method. Biological evaluations included molecular docking, which showed notable α‐amylase inhibition, and MTT assays, which confirmed strong anticancer activity against A549 lung cancer cells. Additionally, the ligand and its complexes demonstrated anti‐Alzheimer's and stress‐resistance effects in Caenorhabditis elegans.