Early experience with a composite ovine forestomach matrix graft in chronic lower extremity wounds: a multi-center retrospective case series

Abstract Chronic wounds place a significant burden on patients and healthcare. A newer outpatient treatment is a composite bioscaffold that contains ovine forestomach matrix and hyaluronic acid (OFM-HA). This multi-center retrospective case series investigated OFM-HA in the treatment of lower extremity chronic wounds. Medical records of 10 patients were reviewed and patient and wound characteristics were documented. Time to 50% percent area reduction (%PAR), time to closure, and complications were evaluated. Patients were primarily elderly with several comorbidities. The mean time to 50% PAR was 3.2 ± 2.3 weeks, and the mean time to closure was 9.9 ± 5.1 weeks. Patients received a median of 4 (IQR: 2, 5) applications. No complications or recurrences occurred. OFM-HA was effective and safe to treat complex lower extremity chronic wounds in the outpatient setting. Moreover, OFM-HA proved to be a durable material, with full closure requiring few applications.