MedicineBiologyEnvironmental Science

Antonella Forlino, Paola Giordani, C. Merla, S. Roda, R. Besio, Abeer Ahmed Qaed Ahmed, A. Kuka, I. Mileto, G. Petazzoni, M. Corbella, P. Cambieri, B. Fausto, A. De Silvestri, Totaro Pasquale, F. Amoroso, Pelenghi Stefano, Maraschi Federica, E. Arbustini, Viviana Vilardo, A. Smirnova, Raffaele Bruno, Seminari Elena

2026.3.1EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

DOI: 10.1111/eci.70188

tlooto Summary

Clinical, microbiological and molecular features of calcified versus non‐calcified aortic regurgitation (AR) valves and a potential role for bacterial colonization in its pathogenesis are investigated.

Abstract

Calcific aortic valve disease (CAVD) is a multifactorial condition characterized by progressive leaflet calcification with a potential role for bacterial colonization in its pathogenesis. This study investigates clinical, microbiological and molecular features of calcified versus non‐calcified aortic regurgitation (AR) valves.

Citation format

FORLINO, Antonella, et al. Infectious seeds of valve calcification: Exploring the bacterial hypothesis in the pathogenesis of calcific aortic valve disease. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2026, 56(3): e70188.