Synergistic Effect of Combination Treatment of Brexpiprazole and Nalmefene on Ethanol Intake in Rats
Naoki Amada, Mai Nakamura, Y. Ohgi, Yusuke Kakumoto, Mikio Suzuki, T. Futamura, Kenji Maeda
2026.3.1Neuropsychopharmacology Reports
tlooto Summary
The effect of nalmefene on ethanol (EtOH) intake was evaluated in Wistar rats, as validation, and effects of brexpiprazole, serotonin–dopamine activity modulator, alone and in combination with nalmefene were evaluated to investigate further treatment option for AUD.
Abstract
Reduction of alcohol consumption is one of treatment goals to reduce harm among individuals with alcohol use disorder (AUD), a major worldwide health problem, for which nalmefene, an opioid receptor modulator, is used. In this study, the effect of nalmefene on ethanol (EtOH) intake, already reported, was evaluated in Wistar rats, as validation. In addition, effects of brexpiprazole, serotonin–dopamine activity modulator, alone and in combination with nalmefene were evaluated to investigate further treatment option for AUD.
Citation format
AMADA, Naoki, et al. Synergistic effect of combination treatment of brexpiprazole and nalmefene on ethanol intake in rats. Neuropsychopharmacology Reports, 2026, 46(1): e70107.