COVID-19 vaccination and rheumatological manifestations: RS3PE syndrome?

Rheumatological manifestations of SARS-CoV-2 infection and COVID-19 vaccination are being repeatedly reported. Herein, we describe a case of a 75-year-old woman who presented with pitting edema of hands and feet and arthritis of small joints following the administration of BNT162b2 (BioNTech-Pfizer) mRNA vaccine. We also discuss potential mechanisms that might explain the occurrence of RS3PE as a rheumatological manifestation of COVID-19 vaccination.