Congenital Self-Healing Reticulohistiocytosis Presenting at Birth: Clinicopathologic Features of a Rare Neonatal Case

Congenital self-healing reticulohistiocytosis is a rare cutaneous form of Langerhans cell histiocytosis that typically manifests in neonates and resolves spontaneously without systemic involvement. We present a case of a male infant who developed multiple papulovesicular skin lesions 2 days after birth. Histopathological examination showed CD1a and S100 positivity, confirming Langerhans cell histiocytosis. The lesions regressed without treatment within 1 month, and no recurrence or systemic involvement was observed during 1.5 years of follow-up. This case underlines the importance of considering congenital self-healing reticulohistiocytosis in neonates presenting with spontaneously regressing skin lesions and highlights the necessity of careful long-term monitoring due to the risk of late systemic involvement or relapse. Awareness of this selflimiting condition can prevent unnecessary interventions and their associated risks.