Response on the commentary on “Relevance of cerebral microbleeds with leaky blood brain barrier in traumatic brain injury and protective role of interferon-gamma: a cohort study”

Highlights • Partial-volume effects impact DCE-MRI and other modalities.• Tractography and structural connectivity (SC) are layers of modelling assumptions.• SC is model-dependent and requires validation against clinical outcomes.• Peripheral sampling is imperfect but practical.• Additional MRI sequences and serial samplings are done in our more recent studies.