CONCENTRATIONS OF TRACE ELEMENTS (COBALT, CHROMIUM, COPPER, SELENIUM, ZINC) IN PATIENTS WITH ABDOMINAL SEPSIS IN THE POSTOPERATIVE PERIOD

Objective. The aim of the study was to examine the dynamics of microelements (cobalt, chromium, copper, selenium, zinc) and the need for their correction in patients with sepsis and multiple organ failure syndrome (MODS) after abdominal surgery. Methods. A prospective observational study was conducted in 45 patients who had surgical pathology of the abdominal organs requiring surgical treatment. All patients were divided into 2 groups: group 1 (n=18) – with the absence of sepsis and MODS; group 2 (n=27) – with the presence of sepsis and MODS. During the 1st day of admission to the anesthesiology and resuscitation department (1st stage), as well as on the 5th (2nd stage) and 10th day (3rd stage) from admission, venous blood was take for determination of cobalt, chromium, copper, selenium, zinc. Results. The level of cobalt was statistically significantly reduced in group 1 compared to group 2 at all stages: in group 1 at stage 1 – 0.4 (0.27-0.66) μg/l, at the 2nd stage – 0.31 (0.24-0.44) µg/l, at the 3rd stage – 0.35 (0.26-0.61) µg/l. Chromium levels were within normal limits in all patients in the study groups. The copper content was statistically significantly lower in group 2 compared to group 1 at all stages: in group 2 at stage 1 – 819.3 (721.5-949) μg/l, at stage 2 – 1st stage – 825.2 (762.5-977.4) µg/l, 3rd stage – 819.7 (759.2-981.5) µg/l. Selenium levels were below normal in group 1: stage 1 – 52.3 (41.5-67.7) µg/l, stage 2 – 51.9 (38.8-63.7) µg /l, stage 3 – 54.8 (33.8-66) µg/l; and in the 2nd group: 1st stage – 47.6 (33.8-66.2) µg/l, 2nd stage – 57.5 (42.7-68.7) µg/l, 3 stage – 47.4 (40.2-57.8) µg/l. A decrease in zinc levels was noted in patients of both groups below normal in group 1: stage 1 – 5624.3 (4911.2-6293.5) mcg/l, stage 2 – 5709.7 (5057.6 -6038.7) µg/l, stage 3 – 5438.5 (4998.8-6168.7) µg/l; and in the 2nd group: 1st stage – 5298.7 (4554.3-6011.4) µg/l, 2nd stage – 5519.5 (4702.4-6315.4) µg/l, 3 stage – 5370.6 (4528.8-6014.8) µg/l. Conclusion. Analysis of the dynamics of the level of concentrations of trace elements showed that the level of copper was lower and the level of cobalt was higher in patients with abdominal sepsis in the postoperative period compared with the comparison group.