EVALUATION OF SERUM INTERLEUKIN-17 AS DIAGNOSTIC MARKERS IN ASTHMA SEVERITY

Asthma continues to be a major health issue worldwide, with an increasing prevalence impacting over 300 million people and contributing significantly to morbidity and mortality.This study investigates the role of interleukin-17 in different asthma phenotypes, focusing on its potential as a biomarker for disease severity and control.The primary aim was to measure & compare the serum levels of IL-17 in asthmatic patients with healthy controls and to explore correlation of IL-17 levels with other inflammatory markers such as IgE, C-reactive protein (CRP), and eosinophil count.Additionally, the study sought to determine the relationship between IL-17 levels and asthma control status.The study encompassed 140 participants, divided equally between asthmatic cases and healthy controls, showing IL-17 levels were elevated in asthma patients though not reaching statistical significance.A clear association was observed between elevated IL-17 levels and other biomarkers with deteriorating control of asthma symptoms.While the direct correlation between serum IL-17 levels and asthma severity was not statistically significant, the study indicates the potential of IL-17 to be a contributing factor in severe asthma cases.Further studies are needed to confirm these findings and assess IL-17's utility in clinical practice for asthma diagnosis and treatment.