Real-World Observations on the Diagnosis of Syphilis After Roll-Out of Doxycycline Postexposure Prophylaxis.

Doxycycline postexposure prophylaxis (doxyPEP) may affect RPR titers. We describe syphilis diagnosis following doxyPEP roll-out. Syphilis diagnoses decreased (3.4%-1.5%) among persons prescribed doxyPEP. Diagnosis without laboratory confirmation occurred frequently in the pre- and post-doxyPEP periods. Median RPR (1:16) did not change; however, it was 4-fold lower (1:4) among persons prescribed doxyPEP.