Haotian Wang, Run Jiao, Liran Ma, Yaoyao Li, Yuemao Shen, Haoxin Wang
2026.2.1Engineering Microbiology
tlooto Summary
Seven novel pentaketide ansamycins were isolated from Streptomyces and were active against Xanthomonas oryzae and Staphylococcus aureus and CYP450 enzyme Tpm16 modulates the bioactivity of pathway intermediates.
Abstract
Highlights • A “cryptic” pentaketide ansamycin gene cluster was activated.• Seven novel pentaketide ansamycins were isolated from Streptomyces.• Compounds 5 and 6 were active against Xanthomonas oryzae and Staphylococcus aureus.• CYP450 enzyme Tpm16 modulates the bioactivity of pathway intermediates.
Citation format
WANG, Haotian, et al. Genome-guided discovery of tropansamycins: Antimicrobial pentaketide ansamycins. Engineering Microbiology, 2026, 6(2): 100263.