Fatemeh Forouzandeh, Abdullah Aldhaher, N. Baheiraei, F. Shams, Ali Doostmohammadi, H. Samimi
2026.2.16Cell Journal
tlooto Summary
The S-Alg/Ce-BG composite scaffold exhibits favorable properties for CTE, including cytocompatibility, enhanced angiogenic potential, and antioxidant activity, which highlight the scaffold as a highly promising candidate for advancing cardiac tissue regeneration strategies.
Abstract
Objective: Cardiovascular diseases remain a leading cause of global mortality and morbidity, despite advances inprevention, diagnosis, and treatment. Cardiac tissue engineering (CTE) offers a promising approach to repairingdamaged myocardium through bioengineered constructs that closely mimic native cardiac tissue. The integrationof biomaterials that enhance angiogenesis, exhibit antioxidant activity, and support cellular proliferation can furtherimprove regenerative outcomes. This study aimed to assess the potential of a sulfated alginate (S-Alg)/cerium-doped45S5 bioactive glass (Ce-BG) scaffold as a cardiac patch for tissue engineering applications.
Citation format
FOROUZANDEH, Fatemeh, et al. Novel sulfated alginate-cerium bioactive glass scaffolds: Promising platform for cardiac tissue regeneration. Cell Journal, 2026, 27 1(1): 1–12.