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Environmental ScienceBiologyMedicine

Reproductive and Neurobehavioral Effects of Combined Exposure to Dinotefuran and Piperonyl Butoxide in an F1 Generation of Mice

Toyohito Tanaka, A. Inomata

2026.2.1Birth Defects Research

DOI: 10.1002/bdr2.70035

tlooto Summary

Evaluated the reproductive and neurobehavioral effects of combined dinotefuran and piperonyl butoxide in an F1‐generation toxicity study in mice to evaluate the reproductive and neurobehavioral effects of combined exposure to neonicotinoid insecticides and synergists in mammals.

Abstract

Few published studies are reported for reproductive and neurobehavioral toxicity of combined exposure to neonicotinoid insecticides and synergists in mammals. This study aimed to evaluate the reproductive and neurobehavioral effects of combined dinotefuran (DIN) and piperonyl butoxide (PBO) in an F1‐generation toxicity study in mice.

Citation format

TANAKA, Toyohito; INOMATA, A. Reproductive and neurobehavioral effects of combined exposure to dinotefuran and piperonyl butoxide in an f1 generation of mice. Birth Defects Research, 2026, 118(2): e70035.