Déja M. Grant, Gwenyth J. Joseph, M. Searcy, Rachelle W. Johnson
2026.1.1Journal of Bone Oncology
tlooto Summary
Spatial profiling reveals region-specific immune and tumor signaling in α-PD-1 treated breast cancer bone metastases, and both the marrow and endosteum enrich pro-tumorigenic pathways, but through distinct mechanisms.
Abstract
Highlights • Spatial profiling reveals region-specific immune and tumor signaling in α-PD-1 treated breast cancer bone metastases.• Immune-suppressive markers are enriched in CD45+ cells in the endosteum of breast cancer bone metastases.• Proliferation and cell death pathways are enriched in tumor cells residing in the marrow vs the endosteum.• Both the marrow and endosteum enrich pro-tumorigenic pathways, but through distinct mechanisms.
Citation format
GRANT, Déja M., et al. Digital spatial profiling of α-PD-1 treated breast cancer bone metastases reveals region-specific signaling and enrichment of immune-suppressive markers. Journal of Bone Oncology, 2026, 57: 100741.