Davide Sposato, Giorgia Molesini, Christopher Riccardi, Jessica Mercolino, Luisa Torrini, Ilaria Varone, Manuela Cipolletti, F. Acconcia, G. Rampioni, L. Leoni, P. Visca, M. Fondi, F. Imperi
tlooto Summary
The lipoprotein-specific signal peptidase LspA is essential in Pseudomonas aeruginosa and a gain-of-function mutation in amgS supports growth under LspA-limiting conditions.
Abstract
Highlights • The lipoprotein-specific signal peptidase LspA is essential in Pseudomonas aeruginosa.• LspA depletion compromises membrane integrity and increases antibiotic susceptibility.• A gain-of-function mutation in amgS supports growth under LspA-limiting conditions.• The membrane proteins HtpX and YccA are required for AmgRS-mediated rescue.
Citation format
SPOSATO, Davide, et al. Activation of the envelope stress-responsive two-component system amgrs compensates for depletion of the essential lipoprotein signal peptidase lspa in pseudomonas aeruginosa. Current Research in Microbial Sciences, 2026, 10: 100565.