Michael V. Berridge, R. Zobalova, Jiri Neuzil
2026.2.1Cell Metabolism
tlooto Summary
It is reported that mitochondrial transfer from non-cancer immune cells to cancer cells in the tumor facilitates lymph node metastasis via the cGAS/STING immune evasion pathway involving type I interferon.
Abstract
Although a role for mitochondrial transfer has been implicated in metastasis, the mechanisms are unclear. Using mouse metastatic models, Okwan-Duodu and colleagues1 report that mitochondrial transfer from non-cancer immune cells to cancer cells in the tumor facilitates lymph node metastasis via the cGAS/STING immune evasion pathway involving type I interferon.
Citation format
BERRIDGE, Michael V.; ZOBALOVA, R.; NEUZIL, Jiri. Metastasis gets a little help from immune cell mitochondria. Cell Metabolism, 2026, 38 2(2): 254–256.