BiologyMedicine

Effects of thymidylate synthase inhibitors differ in genomic uracilation and mutagenic potential

Eszter Holub, G. Papp, H. Pálinkás, Milda Blanka Szajkó, Richard Izrael, G. Róna, B. Vértessy, Angéla Békési

2026.2.6Life Science Alliance

DOI: 10.26508/lsa.202503352

tlooto Summary

It is demonstrated that biased uracilation preferentially affects functionally related genes in a drug-specific manner, highlighting the biological significance of genomic uracilation.

Abstract

Distinct genomic uracil patterns and APOBEC3 activation differentiate cellular responses to TS inhibitors, connecting uracil metabolism to mutagenesis and drug tolerance in colon cancer cells.

Citation format

HOLUB, Eszter, et al. Effects of thymidylate synthase inhibitors differ in genomic uracilation and mutagenic potential. Life Science Alliance, 2026, 9(4): e202503352.