Hypothyroidism associated with anti-epileptic medications: Two case reports.

Anti-epileptic drugs (AEDs) are often the first-line treatment implemented to manage epilepsy (Epilepsy Foundation, 2023). While it is unknown the exact mechanism by which different AEDs impact thyroid hormones, studies have shown that patients on AEDs should have thyroid hormone levels monitored due to possible disruption. This is a case report of two pediatric patients who were referred to the endocrinology clinic for different reasons: one for bone health and one for signs of early puberty. Both patients had been on AEDs for several years when an endocrinology evaluation showed an abnormality in their thyroid hormone levels.