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Medicine

Development and Validation of a Time‐Dependent Nomogram for Predicting Hematological Toxicity Risk During Linezolid Therapy in Drug‐Resistant Tuberculosis

Wenqiang Zhou, Hui Zhu, Zhongquan Liu, W. Nie, Qingfeng Wang, Wenhui Shi, Yang Yang, Wenjie Qi, Yu Lu, Naihui Chu

2026.2.9PHARMACOTHERAPY

DOI: 10.1002/phar.70109

tlooto Summary

This time-dependent nomogram, integrating Cmin with baseline clinical factors, enables early identification of patients with DR-TB at high risk for hematotoxicity and could guide pre-emptive interventions.

Abstract

Linezolid is essential for drug‐resistant tuberculosis (DR‐TB) treatment but causes frequent hematological toxicity. We developed a time‐dependent nomogram to predict this risk.

Citation format

ZHOU, Wenqiang, et al. Development and validation of a time‐dependent nomogram for predicting hematological toxicity risk during linezolid therapy in drug‐resistant tuberculosis. PHARMACOTHERAPY, 2026, 46(3): e70109.