MedicineChemistry
Z. Qiao, Jingli Xu, Fabio Gallazzi, Jing Wang, Charles J. Smith, Yubin Miao
tlooto Summary
The presence and charge of the linker significantly affected MC1R binding and tumor uptake and the linker charge played a key role in the liver and kidney uptake of [177Lu]-Lu-DOTA-Lys-(Asp-p-TBA)-GGNle-CycMSHhex and [177Lu]-Lu-DOTA-Lys-(Glu-p-TBA)-GGNle-CycMSHhex.
Abstract
Lu]-Lu-peptides, highlighting its potential for future melanoma therapy.
Citation format
QIAO, Z., et al. Effect of a negatively charged amino acid linker on the tumor-targeting properties of [177lu]lu-labeled 4‑p‑(tolyl)butyric acid-conjugated alpha-melanocyte-stimulating hormone peptides. ACS Pharmacology & Translational Science, 2026, 9 3(3): 716–724.