tlooto
Sign up
BiologyMedicine

Phage P100 resistance in clinical and foodborne Listeria monocytogenes isolates is associated with adsorption-inhibiting mutations and fitness trade-offs

C. Brieske, Frank Hille, E. Brinks, Hui-Zhi Low, C.M.A.P. Franz

2026.2.1Current Research in Microbial Sciences

DOI: 10.1016/j.crmicr.2026.100575

tlooto Summary

Most mutations occurred in genes associated with WTA glycosylation, and all mutants exhibited impaired P100 phage binding, which led to increased antibiotics sensitivity and serovar 4b-derived mutants showed greater fitness loss.

Abstract

Highlights • Most mutations occurred in genes associated with WTA glycosylation.• All mutants exhibited impaired P100 phage binding.• Gene mutation patterns appeared serovar-dependent.• Serovar 4b-derived mutants showed greater fitness loss than 2a or 2b.• Phage-resistance induction led to increased antibiotics sensitivity.

Citation format

BRIESKE, C., et al. Phage p100 resistance in clinical and foodborne listeria monocytogenes isolates is associated with adsorption-inhibiting mutations and fitness trade-offs. Current Research in Microbial Sciences, 2026, 10: 100575.