Derek P. Narendra, Brent J. Ryan
2026.2.1TRENDS IN NEUROSCIENCES
tlooto Summary
Findings highlight how rare sporadiclike monogenic forms of Parkinson's disease may inform mechanistic and therapeutic stratification.
Abstract
Parkinson's disease comprises multiple biological subtypes and a heterogeneous clinical course. A recent study by Liao et al. identifies CHCHD2 mutations as a mitochondrial entry point that links metabolic dysfunction to α-synuclein pathology. These findings highlight how rare sporadiclike monogenic forms of Parkinson's disease may inform mechanistic and therapeutic stratification.
Citation format
NARENDRA, Derek P.; RYAN, Brent J. CHCHD2 links mitochondrial dysfunction and α-synuclein misfolding in parkinson's disease. TRENDS IN NEUROSCIENCES, 2026, 49(3): 157–158.