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Identification of STEAP4, EPC1, and CLEC1B as non-invasive candidate biomarkers for hepatocellular carcinoma using integrated bioinformatics analysis

Soheyla Khojand, Neda Zahmatkesh, Arezoo Hassani, Zahra Damerchiloo, Zahra Nikoo, Roozbeh Heidarzadehpilehrood

2026.2.1Biotechnology Reports

DOI: 10.1016/j.btre.2026.e00953

tlooto Summary

SteAP4, EPC1, CLEC1B, and LCN2 were identified as the shared non-invasive biomarkers in hepatocellular carcinoma and protein-protein networks were constructed between mRNAs and miRNAs in HCC.

Abstract

Highlight • Cytokine-related pathways dysregulated in hepatocellular carcinoma (HCC)• STEAP4, EPC1, CLEC1B, and LCN2 were identified as the shared non-invasive biomarkers.• Targeted miRNAs were identified, including miR-107, miR-326, GAS5, MALAT1, PRLP0P6, and SNHG1. • Protein-protein networks were constructed between mRNAs and miRNAs in HCC.

Citation format

KHOJAND, Soheyla, et al. Identification of STEAP4, EPC1, and CLEC1B as non-invasive candidate biomarkers for hepatocellular carcinoma using integrated bioinformatics analysis. Biotechnology Reports, 2026, 50: e00953.