Medicine

Eric J. Sorenson, D. Heitzman, Ikjae Lee, Grace E Jang, L. Elman, Ali A. Habib, James Wymer, G. Hayat, Stephen A. Goutman, J. A. Fernandes, M. Floeter, S. Ajroud-Driss, K. Gwathmey, E. Kasarskis, Yasushi Kisanuki, C. lomen-Hoerth, D. Walk, Wendy Johnston, Frank Diaz, N. Maragakis, S. Paganoni, Jaimin S Shah, Björn Oskarsson, L. Zinman, Terry Heiman-Patterson, O. Jawdat, Christina Fournier, Michael T Pulley, Stephen Scelsa, C. Shoesmith, Z. Simmons, Alexander V Sherman, Benjamin N. Hoover, Rebecca Y. Yun, Ken Cheung, Hiroshi Mitsumoto

2026.3.2MUSCLE & NERVE

DOI: 10.1002/mus.70192

tlooto Summary

Data is presented from a 1‐year prospective follow-up study on PLS and efforts to distinguish it from ALS.

Abstract

Primary lateral sclerosis (PLS) is an ultrarare upper motor neuron syndrome with a prognosis unique from classical ALS. The study of PLS is complicated by its rarity and the difficulty distinguishing PLS from ALS. We present data from a 1‐year prospective follow‐up study on PLS and efforts to distinguish it from ALS.

Citation format

SORENSON, Eric J., et al. Prospective validation of the new PLS diagnostic criteria from PLS natural history study: EMG and neurofilament analyses. MUSCLE & NERVE, 2026, 73(6): 976–983.