Dual-action 1 H-1,2,3-triazole-zinc oxide nanohybrids: a promising strategy against microbes and cancer

The rise of drug-resistant infections and cancer highlights the urgent need for new therapeutic agents. This study aimed to synthesize a novel triazole-based compound and its ZnO nanocomposite to evaluate their antimicrobial and anticancer potential. N-(4-nitrophenyl)-1-(4-(N-(pyridin-2-yl)sulfamoyl)phenyl)-1H-1,2,3-triazole-4-carboxamide (NPST) was prepared and combined with zinc oxide nanoparticles (NPST/ZnO NPs). The geometry and bonding type of the compounds were determined using various spectroscopic techniques, including FTIR, UV-visible, XRD, and 1H NMR. The antibacterial activities of NPST and NPST/ZnO NPs were investigated against Bacillus cereus (Gram-positive), Escherichia coli (Gram-negative), and Candida albicans (yeast). The in vitro antimicrobial assay demonstrated minimal inhibitory concentration, minimum microbicidal concentration, and agar well diffusion