Changes in brain morphology over the first year in adult mixed-mechanism mild traumatic brain injury: the role of injury severity factors

Highlights • mTBI is associated with ventricular enlargement.• The ventricular enlargement is particularly pronounced in patients with complicated mTBI.• Complicated mTBI is also characterized by cortical area decreases and subcortical volume loss.• Most of the brain atrophy occurs during the first 3 months after injury and persists at 12 months.• Gray matter/white matter intensity ratio affects measures of cortical thickness.