FOUR-YEAR CUMULATIVE ANTIBIOGRAM DATA OF Staphylococcus Aureus , ENTEROCOCCUS FAECALIS, AND ENTEROCOCCUS FAECIUM ISOLATED FROM BLOOD CULTURES OF ADULT INTENSIVE CARE UNIT PATIENTS

This study aimed to evaluate the antibiotic susceptibility profiles and resistance trends of these bacteria isolated from blood cultures at our hospital between 2021 and 2024. Bacterial identification was conducted using MALDI-TOF MS, while antibiotic susceptibility tests were performed with the Phoenix M50 system. A total of 1,054 S. aureus isolates were evaluated, including 384 MRSA and 670 MSSA. Additionally, 914 E. faecalis and 692 E. faecium isolates were assessed. The S. aureus isolates demonstrated 98-100% susceptibility to vancomycin, teicoplanin, and linezolid. However, susceptibility to ciprofloxacin significantly declined, with MRSA showing a decrease from 81% to 61% (p = 0.002) and MSSA decreasing from 94% to 74% (p < 0.001). In the case of E. faecalis, susceptibility to streptomycin fell from 63% to 52% (p=0.018). Conversely, in E. faecium, susceptibility to linezolid increased from 88% to 95% (p = 0.029). The rate of MRSA was 36.4%, and susceptibility to vancomycin and linezolid remained high at 98-100%. The increase in ciprofloxacin resistance is noteworthy. For both E. faecalis and E. faecium, susceptibility to linezolid, teicoplanin, and vancomycin was above 90%. These findings highlight the importance of infection control and the rational use of antibiotics.