«Obesogenic memory» as a neurobiological mechanism predicting the recurrent course of obesity

Obesity is a significant healthcare problem worldwide. It is associated with a multitude of comorbidities and significantly reduces the quality of life. Success in the study of the pathogenesis of metabolic disorders contribute to development and introduction of innovative technologies into the clinical practice to combat the epidemic of obesity. However, so far the mechanisms involved in weight regain remain not fully understood. Maintaining body weight is regulated by the interaction of many physiological processes. The purpose of this review is to analyze existing studies dedicated to the biological mechanisms leading weight regain after successful treatment of obesity.