Discovery of secondary metabolites from the marine-derived fungus Gamszarea microspora BTBU20212050.
Zhaoli Liu, Kai Zhang, Xiuli Xu, Fuhang Song, Xiaoli Ma, Zhijun Song
2026.2.22NATURAL PRODUCT RESEARCH
tlooto Summary
Two novel metabolites, gamdione and irpexidine C, along with six known compounds, were isolated from the marine-derived fungus Gamszarea microspora and showed weak antifungal activity against Candida albicans.
Abstract
Two novel metabolites, gamdione (1) and irpexidine C (2), along with six known compounds, including irpexidine A (3), (E)-3-methylpent-2-en-1,5-dioic acid (4), (Z)-3-methylpent-2-en-1,5-dioic acid (5), hydroxyphenylacetic acid (6), 1,3-dihydro-2H-indol-2-one (7) and lumichrome (8), were isolated from the marine-derived fungus Gamszarea microspora BTBU20212050. Their chemical structures were elucidated by comprehensive 1D/2D NMR and HRESIMS spectroscopic analysis, and comparison with spectral data reported in the existing literature. Antimicrobial activity assays showed that gamdione (1) displayed weak antifungal activity against Candida albicans.
Citation format
LIU, Zhaoli, et al. Discovery of secondary metabolites from the marine-derived fungus gamszarea microspora BTBU20212050. NATURAL PRODUCT RESEARCH, 2026: 1–8.